Reading Molecular Information
One Molecule
at a Time

Associate Professor of Biochemistry and Molecular Biology · HDR

I develop biological and solid-state nanopores to detect and identify proteins and peptide biomarkers, unravel their conformations and post-translational modifications, and discriminate isomeric variants at the single-molecule level.

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ACS Central Science 2024 nanopore cover artwork

Featured on the cover of ACS Central Science (2024)

26Peer-reviewed articles
2011–2026

1,719Citations
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7Corresponding-author
publications

Internationalcollaborations
Europe · Asia · USA
Canada · Australia

Research focusNanopore sensing
Biomarkers · PTMs
Conformation · Isomers

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ABOUT

Single-molecule nanopore science for molecular diagnostics

At LAMBE, I develop nanopore approaches that connect molecular structure to electrical signatures, with applications ranging from peptide and protein biomarkers to informational polymers and reactive battery species.

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RESEARCH SNAPSHOT

Four complementary research directions

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Biological nanopores

Engineering aerolysin to decode proteins, peptides and molecular information.

Solid-state nanopores

Transport physics and sensing in complex biological media.

Disease biomarkers

Single-molecule detection of clinically relevant peptide biomarkers.

Emerging applications

Digital polymers and lithium–sulfur battery chemistry.