RESEARCH PROGRAMME
My research develops biological and solid-state nanopores as electrical observatories for proteins, peptides, disease biomarkers and sequence-defined polymers.
Connecting pore architecture, molecular transport and quantitative ionic-current fingerprints.
A nanopore experiment is not only a detection event. The amplitude, duration, fluctuations and population structure of an electrical signal report on molecular charge, shape, conformation, dynamics and interactions with the pore. My programme connects these observables to chemically meaningful questions.
Aerolysin is engineered as a highly sensitive electrical reader of proteins and peptides. Pore architecture, internal charge and electrolyte conditions are tuned to control capture, transport and signal resolution.
Solid-state nanopores provide robust platforms for studying confined molecular transport and detecting biomarkers in demanding media. Controlled polymer environments and data analysis extend sensing toward serum-containing samples.
Nanopore fingerprints distinguish closely related biomarkers through differences in terminal residues, stereochemistry, conformation or post-translational modification, including measurements in complex biological matrices.
Nanopore sensing is extended beyond conventional biomolecules toward sequence-defined digital polymers and reactive polysulfides involved in lithium–sulfur battery chemistry.
Pore, membrane, electrolyte, voltage and molecular conditions.
Capture, orientation, translocation, confinement and interactions.
Blockade depth, dwell time, fluctuations and event populations.
Chemical variants, conformers, biomarkers and encoded sequences.
Establishing a mechanistic foundation for confined protein transport and nanopore sensing.
Thermostable viral portal proteins developed as programmable sensing elements.
Nanopore discrimination of a peptide biomarker and its enantiomer.
Electrical identification of subtle peptide states, including proline cis/trans isomers.
Advancing biomarker detection in realistic matrices and reading information encoded in synthetic polymers.
Low-noise ionic-current acquisition and event-level analysis.
Aerolysin sensing, transport control and pore engineering.
Transport in confined media and complex samples.
Proteins, peptides, isomers and post-translational modifications.
Multidimensional fingerprints, classification and machine learning.
Connecting chemistry, conformation and nanopore readout.
Potential collaborations are especially relevant in peptide and protein chemistry, biomarker analysis, sequence-defined polymers, molecular modelling and energy materials.
